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Even in ancient times people are unaware with the existence of living organisms invisible towards the eye, causing disease. As a result, the ancient Greek scientist and doctor Hippocrates expressed this assumption in a single of his operates. But come to grips with their study of mankind has been able only after the Dutch optician van Leeuwenhoek within the XVI century produced the initial essaystone com microscope and saw firsthand the bacteria inside a drop of water. Yet, a lot of within the class scientist denied the existence of pathogens inside just a few centuries soon after the invention of Leeuwenhoek.